KRAS蛋白包含4个结构域。KRAS蛋白由6条β-折叠链和5条-螺旋结构组成，形成两个主要结构域：G结构域和C端结构域。

KRAS protein contains 4 domains.KRAS protein is made up of 6 beta-strands and 5 alpha-helicies, which form two major domains: G-domain and C-terminal.

KRAS的G结构域由残基1-166组成，包括GTP结合口袋，该区域对于下游效应物和GTPase激活蛋白之间的相互之间作用至关重要。

The G-domain  of KRAS, comprised of residues 1-166, includes the GTP-binding pocket, a region within which is essential for the interactions between the putative downstream effectors and GTPase-activating proteins.

G结构域是高度保守的，包括负责GTP-GTP交换的switch Ⅰ和switch Ⅱ区域。

The G domain is highly conserved and contains switch Ⅰ and switch Ⅱ loops, which are responsible for GDP-GTP exchange.

C端是一个包含CAAX基序的高变区，引导翻译后修饰并决定细胞膜锚定，该区域在RAS蛋白的生物活性调控中起着重要作用。/p>

The C-terminal, a hypervariable region including the CAAX motif, guides posttranslational modifications and determines plasma membrane anchoring. This region plays an important role in the regulation of the biological activity of RAS protein.

KRAS新药研发平台

什么是KRAS?

美迪西助力信诺维抗肿瘤1类新药XNW14010（小分子KRAS G12C蛋白共价结合抑制剂）获批临床