KRAS信号的激活是一个多步骤的过程，需要适当的KRAS翻译后修饰，细胞膜定位与效应蛋白的相互作用。

The activation of KRAS signaling is a multi-step process that requires proper KRAS post-translation，plasma membrane-localization and interaction with effector proteins.

在细胞外刺激作用下，从失活的RAS-GDP到激活的RAS-GDP的转化进一步促进了多种信号通路的激活，包括MAPK通路、PI3k 通路和Ral-GEFs通路，其中以MAPK通路的特征最为明显。

In response to extracellular stimuli, the conversion from inactive RAS-GDP to active RAS-GDP further promotes the activation of various signaling pathways, which includes MAPK pathway，PI3k pathway and the Ral-GEFs pathway,among them the MAPK pathway is the best characterized.

RAS-GDP直接与RAF蛋白结合，将RAF激酶家族从细胞质招募到膜上，在细胞膜上二聚化并活化。激活的RAF随后对其下游底物，即MEK and ERk进行一系列磷酸化反应，并传导生长信号。

RAS-GDP directly binds to RAF protein,recruiting RAF Kinese family from cytoplasm to membranes，where they dimerize and become active. The activated RAF subsequently carries out a chain of phospholation reactions to its downstream substrates, MEK and ERk, and propagates the growth signal.

KRAS新药研发平台

什么是KRAS?

美迪西助力信诺维抗肿瘤1类新药XNW14010（小分子KRAS G12C蛋白共价结合抑制剂）获批临床